Curriculum

Course Code Course Name Credit Theoretical Lab/Practical ECTS
PHAR601 ADVANCED RESEARCH METHODS 3 3 0
The research methods course introduces student to principal and modern concepts of research. This course helps the student to build an analytical and systematic link between theory and practice. Students will be able to develop skills in carrying out literature search using electronic databases, catalogues and print media using proper referencing methods, conduct preliminary literature review, familiarize in experimental methods as well as practice analyzing and interpreting data. Students are expected to recognise the significance of technological innovations, professional and ethical responsibilities in research. Students will be able to analyze and present research results in writing and in oral presentations as well as understanding scope and limits of qualitative and qualitative research methodologies.
PSCI601 MOLECULAR APPROACHES IN PHARMACEUTICAL SCIENCES 3 3 0 8
The research methods course introduces student to principal and modern concepts of research. This course helps the student to build an analytical and systematic link between theory and practice. Students will be able to develop skills in carrying out literature search using electronic databases, catalogues and print media using proper referencing methods, conduct preliminary literature review, familiarize in experimental methods as well as practice analyzing and interpreting data. Students are expected to recognise the significance of technological innovations, professional and ethical responsibilities in research. Students will be able to analyze and present research results in writing and in oral presentations as well as understanding scope and limits of qualitative and qualitative research methodologies.
PSCIXX1 AREA ELECTIVE 3 3 0
PSCIXX2 AREA ELECTIVE 3 3 0
Course Code Course Name Credit Theoretical Lab/Practical ECTS
PHIL601 Philosophy of Science 3 3 0 7
This course will follow three main paths: Firstly it will introduce philosophy to doctoral students. The meaning of philosophy, its scope, its sub-branches and its different schools will be the subject topic of the first weeks. Then the course will focus on the relation of philosophy with the sources of knowledge and different sciences. Here, Rationalism, Empiricism and Intuitionism will be covered during the following weeks. In the remaining weeks the course will concentrate on philosophy of science and scientific ethics. Logical positivism, paradigm changes, falsificationism, the questions of “what is science”, “what is pseudo-science?”, “what is the relation between theory and reality?” are amongst topics that will be covered. Finally, the course will concentrate on ethical theories and will particularly cover scientific ethics.
PSCI602 ADVANCED PHARMACEUTICAL AND BIOMEDICAL SCIENCES 3 3 0 8
This multidisciplinary, integrated course, introduces the students to the modern concepts and applications used in biomedical and pharmaceutical sciences. This course, focused on principles of carrying out laboratory based, molecular, basic research, covers main techniques and technologies used in pharmaceutical and biomedical sciences as well as providing information on their daily use in research labs. Students are expected to learn and effectively used several search portals to access prominent papers in the field and read/reference/present the discussed techniques/discoveries effectively. They are also expected to write and present research proposals covering the discussed techniques and topics as well as evaluating their and their peers’ work critically.
PSCI690 SEMINAR 0 1 0 8
In the seminar course, students are expected to carry out literature review on the particular subject they are planning to develop their theses on. Students are expected to use published research articles and the electronic databases that they are presented on efficiently and excell at reaching the information needed to carry out a successful research project. While carrying out literature review, students will also be trained on forming a hypothesis and gaining critical thinking skills to reach the ability in critically evaluating both published and ongoing work as well as the project that they will be working on to complete their theses. The seminar course will introduce the students with scientific writing skills as well as enhancing their presentation skills in group setting.
PSCIXX3 AREA ELECTIVE 3 3 0
Course Code Course Name Credit Theoretical Lab/Practical ECTS
PSCI600 THESIS 0 0 0 30
This course includes supervisor independent research on a topic agreed between the student and the supervisor (a faculty member) that is also approved by the Administrative Committee of the institution of Graduate studies. Research leads to production of a thesis. It must provide contributions to the field of pharmaceutical sciences. Student must register to this course on no later than the fourth semester of his/her PhD. study. Thesis will be evaluated by a jury of five members of the university and two from other universities. The jury will decide if the subject is relevant to overall aims and objectives of the program and if the university facilities can cover the whole process.
PSCI650 QUALIFYING EXAM 0 0 0
Course Code Course Name Credit Theoretical Lab/Practical ECTS
PSCI624 BASICS IN PHARMACOLOGY 3 3 0
Topics include the terms and definitions in Pharmacology, drug nomenclature, drug classification, drug formulations, principles of rational drug usage, mechanisms for diffusion and transport of drugs within the body, routes for drug administration, principals of drug absorption, distribution, metabolism and excretion, apparent volume of distribution and clinical importance, clinical concepts for drug clearence, adjustment of drug dosages in hepatic and renal disorders, factors influencing drug pharmacokinetics and pharmacodynamics, reasons of variability in drug responses between individuals, drug-drug, drug-diet and drug-test interactions, pharmacogenetic and pharmacogenomic aspects in drug action, drug usage in special patient populations such as childhood, elderly and pregnancy, theories for mechanisms of drug effect, and concentration-effect relationships.
BIOE502 TECHNIQUES IN TISSUE CULTURE AND CELLULAR BIOENGINEERING 3 3 0
This is a course will begin with introducing practical skills for the isolation of animals cells for in vitro studies, maintenance of animal cells in vitro, manipulation of animal cells in vitro, and application of molecular techniques to in vitro situations. This course also designed to bridge cell biology with engineering. At the completion of this course, the students should be able to: Discuss the molecular and cellular basis of life from an engineering perspective, identify crucial molecular parameters involved in cellular events measure and manipulate molecular parameters experimentally, apply engineering principles, concepts, and mathematical modelling in studying molecular parameters, cell structure, function, and appropriately capture the salient features of the cellular phenomena. In addition, the students should be able to manipulate the behaviour of biological cells, examine structure-function relationship and explore and criticize the existing and emerging technologies that exploit and extend our knowledge of molecular and cell biology.
BIOE636 METABOLISM AND CELLULAR ADAPTATION 3 3 0
PSCI623 CHRONOBIOLOGY AND CHRONOPHARMACOLOGY 3 3 0
The main topics are molecular basis of biological rhythms, internal clocks and their messengers, principles of clinical chronobiology, physiology and pharmacology of melatonin, data processing in chronobiological studies, rhythmic variations in the activity of gastrointestinal, hepatic, renal, respiratory, cardiovascular, endocrine systems in healthy and unhealthy conditions, chronobiology of human sleep and sleep disorders, chronobiology of blood pressure and chronotherapy in cardiovascular disorders, nocturnal asthma and chronotherapy, chronobiology in laboratory medicine, cancer chronobiology and treatment approaches, and administration time dependent differences in pharmacokinetics and pharmacodynamics of drugs. Chronobiological implications for the treatment of sleep disorders, chronotoxicology, pain management and shift-work related outcomes of health will also be considered.
PRCO512 MORPHOLOGICAL AND MICROSCOPIC DEFINITIONS OF VEGETABLE DRUGS 3 3 0
PSCI607 MEDICINAL SIGNIFICANCE OF NATURAL PRODUCTS 3 3 0
The natural products obtained from plants, microorganisms, algae etc. and their biomedical uses will be studied in this course. A discussion of bioassay-directed screening, the isolation, structure determination, biosynthesis, partial synthesis and total chemical synthesis of organic natural products of medicinal significance. Examples of the classes of compounds to be considered include steroid hormones, cardiac glycosides, alkaloids, antibiotics, terpenes, and the like. Different plants used in pharmaceutical sciences and biomedical sciences as well as the potential of not yet studied plants will be evaluated. Extraction methods aimed at extracting the active ingredients and the methods used to test these ingredients on eukaryotic and prokaryotic cells will be discussed.
BIOE504 OPTICAL IMAGING TECHNIQUES 3 3 0
Students will attend lectures on the theory and underpinnings of optical imaging techniques in bioengineering, including light, fluorescent and electron microscopy and imaging. Emerging techniques such as “optogenetics” will also be covered. Practical instruction will be given in the use of light, fluorescent and electron microscopes, with samples prepared by the students.
BIOE531 FERMENTATION MICROBIOLOGY 3 3 0
PRCO503 İLERİ FARMAKOGNOZİ-I 3 2 2 0
The plant and animal kingdom as source of drugs, General methods associated with the phytochemical investigation pf herbal products; Extraction of plant Material, separation and isolation of constituents: Sublimation, distillation, Fractional liberation, fractional chrystallization, Adsorbsion chromatography, Partition chromatagraphy, High performance liquid chromatography (HPLC), ThinLayer Chromatography(TLC), Gas-Liquid chromatography, Gel filtration chromatography, Electrochromatography, Basic metabolic pathways and the origin of secondary metabolites; Enzymes, Photosynthesis, Carbohydrate utilization, Glycosides, Fats and Fatty acids,, Aromatic biosynthesis, The shikimic acid pathway, The acetate hypothesis Amino acids biosynthesis, Peptides and proteins, Isoprenoid compounds The mevalonic acid pathway, Secondary metabolites, Stress compounds, Discovering new lead compounds in pharmaceutical research and development. Phytochemical variation within a species.
PSCI605 RESEARCH ETHICS 3 3 0
Ethical aspects of research, both at the clinical, molecular and pharmaceutical level are discussed in this course. Ethical regulations of drug research in humans, local and national ethics committees, duties and responsibilities of the Declaration of Helsinki, regulations about the drug research, good clinical practice guidelines, good laboratory practices, bias in research and clinical trials, randomization, blinded and nonblinded trials, informed written consent, placebo-ethics, nocebo-ethics, special patient groups and private drug trials on the methods to be used in children, pregnant women and the elderly, drug research, drug research about the regulations. Using experimental controls and interpretation of experimental results that will ultimately affect human life and well-being will also be discussed.
PSCI608 MOLECULAR MICROBIOLOGY AND MICROBIAL PATHOGENESIS 3 3 0
The molecular mechanisms utilized by microbes of different sorts used in pathogenesis are covered in the Molecular Microbiology and Microbial Pathogenesis course. The methods used by bacteria, viruses and parasites in causing disease are thoroughly discussed as well as mechanisms associated with drug efficacy and resistance. Molecular pathways used by microorganisms to assemble virulence factors and host-pathogen interactions are discussed with the help of primary research articles. The students are encouraged to apply molecular techniques in microbiology as part of writing proposals and presentations as well as reading articles to present in journal clubs. Students are expected to critically review and evaluate published papers in the field.
BIOE535 BIOTECHNOLOGY 3 3 0
BIOE628 CANCER BIOLOGY 3 3 0
BIOE633 SPECIAL TOPICS IN BIOENGINEERING II 3 3 0
HCOM567 HEALTHCARE, TECHNOLOGICAL DEVELOPMENTS AND DIGITALIZATION 3 3 0 0
Technological developments and digital technologies change lives and completely reconstruct the health environment. Digital developments take patients to the center, and a new status quo and new roles are emerging for both the patient and health professionals and specialists. To this end, this course will inform the health sector employees of developments and new technologies and will increase the awareness of the participants about digitalization. The course will focus on developments and changes in the sector. The trends that shape the future of health and medicine, strengthened patients, health games, augmented reality and virtual reality, telemedicine and remote care, personalized medicine, and hospitals of the future are among the topics to be covered in this course.
PSCI609 ADVANCED BIOTECHNOLOGY 3 3 0
In this course molecular techniques used in biotechnology and biotechnological tools are discussed. Students are expected to be able to fully classify, implement and express the molecular basis of major biotechnology techniques. Describing, applying and assessing the basic principles and techniques of pharmaceutical biotechnology are among the covered topics. In this course, students will learn how to illustrate, judge and critically evaluate the important features of new advances in pharmaceutical biotechnology as well as being able to search and interpret multidisciplinary scientific articles. As part of the interactive course plan, the students will also get to gain experience in critically reflecting, summarizing and presenting on biotechnology methods and techniques using scientific literature.
PSCI619 INJECTABLE DOSAGE FORMS 3 3 0
Pyrogen and control methods, water purification (FILTRATION) ion exchange, reverse osmosis, distillation, heat transfer, water for injection free from dissolved gas, CO2 free water are the main subjects which will be discussed in this course. Routes of administration, solvent used for parenteral dosage forms will be covered. Besides, hardness of water, types of water, water purification methods , distillation, as well as heat transfer, pyrogen tests, storage of water, CIP and SIP, formulation of injectable dosage forms, visual inspection and automatic inspection systems; mixing vessels, types of stirrers, isotonicity, dialysis solutions, filtration, sterilization, containers consisting of glass and plastic; closures, washing of containers and closures; filling of ampules, HVAC system, environmental cleanliness will be widely discussed in this lecture.
PSCI628 POISONOUS PLANTS 3 3 0
In this course, the important poisonous plants used in the Mediterranean countries and their characteristics will be introduced. Information will be given about the regions where the plants are distributed, their characteristics and the points that should be taken into consideration in their use for therapeutic purposes. The Family and the genus of the species like Digitalis ferruginea (Scrophulariaceae), Atropa belladonnae (Solanaceae), Aconitum napellus (Ranunculaceae), Colchicum autumnale (Liliaceae), Matricaria chamomilla and Echinacea purpurea (Asteraceae), which of them have ethnobotaniccal use to threat various diseases. Plant collection, drying, storage and how to use the plants will be described. Due to the toxic compounds they contain, information will be given about the issues needs to be taken into consideration during use. In addition, literature review of poisonous plants with medicinal use will be explained.
PHIL601 Philosophy of Science 3 3 0 7
This course will follow three main paths: Firstly it will introduce philosophy to doctoral students. The meaning of philosophy, its scope, its sub-branches and its different schools will be the subject topic of the first weeks. Then the course will focus on the relation of philosophy with the sources of knowledge and different sciences. Here, Rationalism, Empiricism and Intuitionism will be covered during the following weeks. In the remaining weeks the course will concentrate on philosophy of science and scientific ethics. Logical positivism, paradigm changes, falsificationism, the questions of “what is science”, “what is pseudo-science?”, “what is the relation between theory and reality?” are amongst topics that will be covered. Finally, the course will concentrate on ethical theories and will particularly cover scientific ethics.