CIU-Guldal-Mehmetcik

Prof. Dr. GÜLDAL MEHMETÇİK

Faculty of Medicine

Role Dean
Telephone number +90 392 671 11 11
Extension 2659
Office No.
Other information

CURRICULUM VITAE

Education
  • İstanbul University,İstanbul Faculty of Medicine -Biochemistry (PhD, 1994)
  • İstanbul University,İstanbul Faculty of Medicine -Biochemistry (Professional Doctorate, 1989)
  • Greenwich University -Applied Sciences B.Sc (Undergraduate, 1984)
Publications

Articles published in peer reviewed international journals (SCI,SSCI,Arts and Humanities)

  • Salman Z, Yılmaz T, Mehmetçik G. (2018)The relationship between ferritin levels and oxidative stress parameters in serum of β-thalassemia major patients. Arch Biochem Biophys. 2018 Dec 1;659:42-46. doi: 10.1016/j.abb.2018.09.020. Epub 2018 Oct 1. - 2018
  • Becer E, Mehmetçik G, Bareke H, Serakıncı N (2013). Association of leptin receptor gene Q223R polymorphism on lipid profiles in comparison study between obese and non-obese subjects. Gene ; 529: 16-20. - 2013
  • Küçükgergin C, Aydın AF, Ozdemirler-Erata G, Mehmetçik G, Koçak-Toker N, Uysal M Effect of Artichoke Leaf Extract on Hepatic and Cardiac Oxidative Stress in Rats Fed on High Cholesterol Diet. . Biol Trace Elem Res. Volume: 135 Issue: 1-3 Pages: 264-274 , 2010June - 2010
  • Küskü-Kiraz Z, Mehmetçik G, Dogru-Abbasoglu S, Uysal M. Artichoke leaf extract reduces oxidative stress and lipoprotein dyshomeostasis in rats fed on high cholesterol diet. Phytother Res. Volume: 24 Issue: 4 Pages: 565-570 Published: APR 2010 4- - 2010
  • Kusku-Kiraz Z, Mehmetcik G, Dogru-Abbasoglu S, Effect of artichoke extract on peroxidation status on apo-b-containing lipoproteins and serum lipid composition in rats fed on high cholesterol diet Author(s): et al. Source: IUBMB LIFE Volume: 61 Issue: 3 Pages: 389-389 Published: MAR 2009 - 2009
  • Parıldar-Karpuzoğlu H,Mehmetçik G,Özdemirler-Erata G,Doğru-Abbasoğlu S,Koçak-Toker N,Uysal M Effect of taurine treatment on pro-oxidant balance in livers and brains of old rats Pharmacol Rep .2008 Sep-Oct,60 (5):673-8. - 2008
  • Mehmetçik G, Ozdemirler G, Koçak-Toker N, Cevikbaş U, Uysal M. Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress. Exp Toxicol Pathol. 2008 Sep;60(6):475-80. Epub 2008 Jun 25. - 2008
  • Parildar H, Dogru-Abbasoglu S, Mehmetçik G, Ozdemirler G, Koçak-Toker N, Uysal M. Lipid peroxidation potential and antioxidants in the heart tissue of beta-alanine- or taurine-treated old rats. J Nutr Sci Vitaminol (Tokyo). 2008 Feb;54(1):61-5. - 2008
  • Mehmetçik G, Ozdemirler G, Koçak-Toker N, Cevikbaş U, Uysal M. Role of carnosine in preventing thioacetamide-induced liver injury in the rat. Peptides. 2008 Mar;29(3):425-9. Epub 2007 Nov 22. - 2007
  • Balkan J, Kanbağli O, Mehmetçik G, Mutlu-Türkoğlu U, Aykaç-Toker G, Uysal M. Increased lipid peroxidation in serum and low-density lipoproteins associated with aging in humans. Int J Vitam Nutr Res. 2002 Oct;72(5):315-20. - 2002
  • Mehmetçik G, Ozdemirler G, Kanbagli O, Toker G, Uysal M. Age-related changes in plasma lipid peroxidation and antioxidant system in humans and rats. Arch Gerontol Geriatr. 1997 Nov-Dec;25(3):305-10. PMID: 18653118 [PubMed - in process] - 1997
  • Mehmetçik G, Toker G, Uysal M. Endogenous and copper-induced lipid peroxidation and antioxidant activity of serum in hypercholesterolemic subjects. Horm Metab Res. 1997 Feb;29(2):63-5. - 1997
  • Alptekin N, Mehmetçik G, Uysal M, Aykaç-toker G. Evidence for oxidative stress in the hepatic mitochondria of bile duct ligated rats. Pharmacol Res. 1997 Sep;36(3):243-7. Evidence for oxidative stress in the hepatic mitochondria of bile duct ligated rats. Pharmacol Res. 1997 Sep;36(3):243-7. - 1997
  • Mehmetçik G,Alptekin N,Toker G,Uysal M. Mitochondrial lipid peroxides and antioxidant enzymes in the liver following phrone-induced Gluthathione depletion. Res Commun Mol Pathol Pharmacol.1997 June;96(3):353-6. - 1997
  • Ozdemirler G, Mehmetçik G, Oztezcan S, Toker G, Sivas A, Uysal M. Peroxidation potential and antioxidant activity of serum in patients with diabetes mellitus and myocard infarction. Horm Metab Res. 1995 Apr;27(4):194-6. - 1995
  • M Uysal 1, G Kutalp, G Ozdemirler, G Aykaç, Ethanol-induced changes in lipid peroxidation and glutathione content in rat brain Drug Alcohol Depend.1989 Jun;23(3):227-30. . - 1989
  • Uysal M, Ozdemirler G, Kutalp G, Oz H. Mitochondrial and microsomal lipid peroxidation in rat liver after acute acetaldehyde and ethanol intoxication. J Appl Toxicol. 1989 Jun;9(3):155-8. - 1989
  • Uysal M, Seçkin S, Kutalp G, Koçak-Toker N. Erythrocyte lipid peroxidation, glutathione and vitamin E levels in cholesterol-fed rats. Int J Vitam Nutr Res. 1988;58(2):198-201. - 1988
  • -Uysal M, Kutalp G, Seçkin S. The effect of cholesterol feeding on lipid peroxide, glutathione, glutathione peroxidase and glutathione transferase in the liver of rats. Int J Vitam Nutr Res. 1988;58(3):339-42. - 1988

Papers presented in international conferences and printed as proceedings

  • Becer E. Özkök E,Yanar F , Başar Y ,Salmayenli N , Mehmetçik G. Free Radical Biology and Medicine 65 (2013) S23–S56 ,Serum VEGF, CD40L and NO levels in Peripheral Arterial Disease, Free Radical Biology and Medicine ,65 (2013) 23-56 - 2013
  • Becer E.,Mehmetçik G. Plasma Malondialdehyde and Erythrocyte Superoxide Dismutase Levels in Obesity,  Free Radical Biology and Medicine (2013) .65 : 25 – 26. - 2013
  • İstanbul Tıp Fakültesi 10. Kurultayı, İstanbul, 18-22 Eylül 1989 1.G .Kutalp,G.Özdemirler,N.Koçak,M.Uysal,:Akut ve kronik asetaldehit uygulanan sıçanlarda karaciğer lipit peroksit ve glutatyon düzeyleri. - 1989

Articles published in National journals

  • Mehmetçik G., Becer E., Akbey A. (2012). Serum total antioxidant status, lipid profile, malondialdehyde and erythrocyte superoxide dismutase levels in Hashimoto thyroiditis patients treated with levothyroxine. Türkiye Klinikleri J Med Sci, 32(5), 1241-6. - 2012
  • Uysal, M., Koçak-Toker, N., Kutalp, G., Özdemirler, G., Öz, H.,: Lipid peroxide levelsand Na-K-ATPase activities in brain homogenates from young and old mice, Turk. J. Med.. Biol. Res., 2:47-50,1991 - 1991
  • -Koçak-Toker, N., Kutalp, G., Özdemirler, G., Uysal, M.,: The effect of acute and chronic acetaldehyde treatments on hepatic lipid peroxide levels in rats, Turk. J. Med. Biol. Res., 1:117-120,1990. - 1990
  • Özdemirler ,G., Kutalp, G., Uysal, M., Öz, H.,: Akut etanol uygulanan sıçanlarda karaciğer mitokondri ve mikrozomal fraksiyonlarda malondialdehit ve dien konjugat düzeyleri, Tıp fak 11.6.. Mecm., 52:667-672,1989. - 1989

Papers presented in National conferences and printed as proceedings

  • İstanbul Tıp Fakültesi 12. Kurultayı, İstanbul, 12-16 Ekim 1993 1. Öztezcan, S., Özdemirler, G., Mehmetçik, G., Toker, G., Uysal, M.: Serumun lipid peroksidasyon duyarlılığı ve antioksidan üzerne incelenmesi. - 1993
  • XVI. Ulusal Kongresi – 1990 Kasım G. Kutalp, G. Özdemirler, N. Koçak-Toker, 91. Uysal: In vivo lipit pecksidasyon ölçümlerinin karşılaştırılması. - 1990
  • IX. Ulusal Biokimya Kongresi, Antalya, 19-23 Kasım 1989 Öz, H., Kutalp, G., Özdemirler, G., Uysal, M,: Genç ve yaşlı farelerin beyin homojenatlarında lipid peroksit düzeyleri ile Na-K-ATP ase aktitivitesi, Biyokimya Dergisi, 14:240,1989 - 1989
  • IX. Ulusal Biokimya Kongresi, Antalya, 19-23 Kasım 1989 1. Kutalp, G, Özdemirler, G., Koçak-Toker, N., Uysal, M.,: In vivo lipid peroksidasyonu ölçümlerinin karşılaştırılması, Özet kitabı, s.97. - 1989
  • Tıp Kongresi-88, Girne-Kıbrıs, 9-13 Ekim 1988 1. Uysal, M., Özdemirler, G., Kutalp, G., öz, H.,: Akut etanol uygulamasının sıçan karaciğerinin mitokondri ve mikrozomal fraksiyonlarında lipid peroksidasyonu üzerine etkisi, program ve Serbest Bildiriler Kitabı, s.23. - 1988
  • Tıp Kongresi-88, Girne-Kıbrıs, 9-13 Ekim 1988 1. Uysal, M., Kutalp, G., Özdemierler, G., Toker, G.,: Akut ve kronik etanol uygulanmasının sıçanların beyin lipid peroksit ve glutatyon düzeyleri üzerine etkisi, Program ve serbest bildiriler kitabı, s.37 - 1988
  • XIV.Ulusal Kongresi, Pamukkale,Denizli11-12 Kasım 1988 -Öz, H., Kutalp, G. Özdemirler, G., Uysal, M.,:Yaşlanmanın farelerin beyin lipid peroksit ve (Na-K)ATP az aktivitesi üzerine etkisi, Özet Kitabı, s.76-77. - 1988
  • XIV.Ulusal Kongresi, Pamukkale,Denizli11-12 Kasım 1988 Kutalp, G., Özdemirler, G., Koçak-Toker, N.,: Akut ve kronik asetaldehit uygulanan sıçanlarda karaciğer lipit peroksit ve glutatyon düzeyleri, Program ve Serbest Bildiriler Kitabı 1.,s.87-88. - 1988
  • VIII. Türk Farmakoloji Kongresi, Antalya, 31 Ekim-2 Kasım 1986 1. Uysal, M., Özdemirler, G., Kutalp, G., Öz, H.: Effects of acetaldehyde and ethanol on lipid peroxidation in hepatic subcellular organelles in rats, Marmara Medical Journal, 1:59, 1988. - 1988
  • VIII. Türk Farmakoloji Kongresi, Antalya, 31 Ekim-2 Kasım 1986 1. Uysal, M., Kutalp, G., Özdemirler, G., Öz, H.: Effect of acute dose of acetaldehye on lipid peroxidation and the content of glutathione in rat liver and brain, Marmara Medical Journal, 1:60,1988. - 1988
  • VIII. Türk Farmakoloji Kongresi, Antalya, 31 Ekim-2 Kasım 1986 1. Seçkin, Ş., Kutalp, G., Koçak-Tokaer, N., Uysal, M.,: Kolesterolce zengin dietle beslenen sıçanlarda eritrosit lipitleri, lipit peroksit, glutation ve vitamin E düzeyleri, Biokimya Dergisi, 12:7,1987. - 1987
Thesis Supervision

Master Thesis Supervised

  • Investigation of lipid peroxide and antioxidant activity in Hashimoto Patients
  • Investigating the relationship between metabolic syndrome and insulin resistance in N.C.T.R.
  • Lipid storage diseases
  • Effect of cinnamon on some biochemistry parameters
  • Research of the biological effects of black seed
  • Malondialdehyde and C-reaktif protein values in transfusion dependent Beta Thalassemia patients

Doctorate Thesis Supervised

  • Investigating the relationship between leptin,adiponectin,resistin, insulin resistance and Q223R polymorphism in obese subjects.
Projects
  • Investigating the relationship betwee diabettes,Arteriosclerosis and metabolic syndrome.
Awards
  • NEU Research Award
  • NEU Research Award
  • NEU Research Award
Research Areas
  • Oxidative stress,anioxidant system,arterosclerosis,thalasemia,liver injury
Administrative Duties
  • Dean of Faculty of Medicine(CIU)
  • Head of Biochemistry Department Faculty of Pharmacy(NEU)