The Effects of Gene Mutations on Cancer Treatment discussed at CIU
The importance of Polymorphisms in Xenophobic/Drug Metabolizing Enzymes in Chemotherapy and Lung Cancer was discussed at Cyprus International University (CIU).
Prof. Dr. Mümtaz İşcan, who spoke at the event organized by the Faculty of Pharmacy, gave information about the interaction of drugs and foreign chemicals involved in the metabolism of some genes producing polymorphisms of the enzyme.
İşcan also talked about the polymorphisms of genes in lung cancer patients with respect to life expectancy, age response, and differences in response to chemotherapy. He said CYP and GST gene polymorphisms in response to chemotherapy have played an important role.
In his speech, İşcan explained that p53 is a tumor suppressor gene and discussed the effects of polymorphisms in this gene on cancer treatment.
İşcan said mutated genes cannot benefit from the drug enough by transferring, according to the mutation of the chemotherapy drugs given to patients, which effects the response in a positive or negative way.
İşcan pointed out that lung cancer is a common type of cancer in Turkey and he reported that investigations were done on the origin of the deaths caused by this cancer. İşcan said research was done to show how the polymorphic gene mutations change the response to the drug.
Assist. Prof. Dr. Ender Volkan Çınar, Vice Dean of the Faculty of Pharmacy, CIU, noted the purpose of the event, stating that they organized it to inform students about the new scientific developments and research and to develop a research culture. Çınar, İşcan and his team's findings that gene mutations affect the response to the treatment of cancer may play an important role in personalized medicine in the future.